Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the ...

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

A comprehensive encyclopedia of the known functions of all protein-coding human genes has just been completed and released. Researchers used large-scale evolutionary modeling to integrate data on ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

For millennia, evolution has intrigued many great thinkers, prompting questions about how new traits emerge as species adapt over time. Then, attention shifted to natural selection and the inheritance ...

Thousands of new genes are hidden inside the “dark matter” of our genome. Previously thought to be noise left over from evolution, a new study found that some of these tiny DNA snippets can make ...

Discovery of genetic glitches in gene formatting (RNU4-2 mutations) discloses a new cause for blindness, solving retinal ...

In patients with retinitis pigmentosa (RP), crucial cells in the retina known as rods and cones die over time; night ...